Immunohistochemistry was performed to analyze the expression of GSK-3β, PTEN, and PDL1. Methods: We evaluated 95 lung cancer specimens from biopsies and surgical resections. This study investigated the correlation between GSK-3β expression and clinically relevant molecular features of lung adenocarcinoma (PDL1 score, PTEN expression and driver mutations). GSK-3β phosphorylates target pro-oncogenes and regulates programmed cell death-ligand 1 (PD-L1).
3Departments of Patholoy, Oncology and Thoracic Surgery, Messejana Heart and Lung Hospital, Fortaleza, Brazil.2Argos Pathology Laboratory, Department of Investigative Pathology, Fortaleza, Brazil.1Department of Pathology, Federal University of Ceará, Fortaleza, Brazil.
Marclesson Alves 1, Daniela de Paula Borges 2, Aline Kimberly 1,2, Francisco Martins Neto 3, Ana Claudia Oliveira 3, Juliana Cordeiro de Sousa 1,2, Cleto D.
